Based on a comprehensive NGS and clinical data analysis in TCGA BRCA patients, a functional link was established between KDM7A-DT overexpression and an aggressive cancer cellular phenotype associated with genome instability (GI), copy number alterations (CNAs), aneuploidy, TP53 mutational status, and critical BRCA-associated transcriptional pathways. The gene discussed is TP53; the disease is cancer.