SMAD3 and neoplasm: In contrast the genes that were significantly negatively correlated to KDM7A-DT expression exhibited an even mixture of all ITI categories, with four (N=4) belonging to the ITI category 3 ‘decreased’ invasive tumor properties (TP53BP1, BCL2L11, SMAD3, and ARID1A), six (N=6) to the ITI category 1 (increased) and nine (N=9) to category 2 (affected).