In this study, through univariate and multivariate analyses of ORR, it was determined that PD-L1, TMB, and neutrophils were independent prognostic factors of ORR in patients with NSCLC, and the AUC values of the ROC curves based on the three indices were 0.7104, 0.7139, and 0.7131, respectively, indicating that the three have good predictive efficiency. This evidence concerns the gene CD274 and non-small cell lung carcinoma.