Moreover, genotoxic chemotherapies induced CARP-1 phosphorylation in additional HBC cells, human mammary epithelial cells (HMECs), human renal epithelial HK2 cells (13), as well as murine C2C12 myoblast cells (32), HC11 murine breast epithelial cells (33), and W0069 BRCA-deficient mouse mammary tumor cells (34) but failed to promote CARP-1 phosphorylation in wild-type murine MEFs as well as murine cardiomyocytes (Figures 4B, C). This evidence concerns the gene CCAR1 and breast cancer.