The patients with choroidal melanoma were divided in two immune subgroups of tumor microenvironment. Class1 has low immune infiltration, contains memory B-cells, T helper-2 cells, T helper-17 cells, natural killer cells and eosinophilic granulocytes, and has a better prognosis. CD8+ T cells, T helper-1 cells, myeloid-derived suppressor cells, and dendritic cells are enriched in class2, which has strong cytolytic activity, high expression of immune checkpoint genes, and poor outcome. The gene discussed is CD8A; the disease is neoplasm.