The risk of ED-AKI increased with age (p < 0.0001), plasma neutrophil gelatinase-associated lipocalin (pNGAL) at 12 h following index admission (p < 0.001), higher baseline serum creatinine, lower baseline eGFR, and chronic kidney disease (p < 0.001), cardiovascular disease, heart failure, hypertension, diabetes, and higher Charlson Comorbidity Index Score (p < 0.001). The gene discussed is LCN2; the disease is chronic kidney disease.