Multiple important risk factors for ED-AKI include increased age, nursing home residency, previous hospital admission within 30 days, higher environmental temperature, serum creatinine, bilirubin, C-reactive protein, white blood cell, alanine aminotransferase (ALT), and lower serum sodium and albumin; diabetes, urological obstruction, sepsis, and gastrointestinal medical conditions, higher pre-admission mean creatinine, lower baseline eGFR, CKD, prior history of AKI, lung disease, hyperlipidemia, infections and antibiotics use. This evidence concerns the gene CRP and Sepsis.