Furthermore, we revealed that objective long sleep duration was associated with peripheral and neuroimaging biomarkers for Alzheimer’s disease and neurodegeneration (e.g. higher plasma Aβ40 and t-tau, a lower Aβ42/Aβ40 ratio and lower total grey matter volume) but not for cerebral microvascular lesions (e.g. serum adhesion molecules ICAM-1 and VCAM-1 and WMH volume, EPVS and lacunes). This evidence concerns the gene VCAM1 and early-onset autosomal dominant Alzheimer disease.