(bai zhu), they decreased microglial activation, conferred protection to dopaminergic neurons, protected dopaminergic neurons from apoptosis, inflammatory cytokines and oxidant protein, attenuated transcriptional activities of NF-κb and MAPK phosphorylation in PD mouse models or in vitro experiments (More and Choi, 2017a,b; Jeong et al., 2019; Li H. et al., 2022). Here, NFKB1 is linked to Parkinson disease.