GPX4 and Parkinson disease: (bai shao), it exerted neuroprotective, anti-ferroptosis, anti-neuroinflammatory, antioxidant and anti-apoptosis effects in PD mouse models and in vitro research, via regulating the α-synuclein/PKC-δ, Bcl-2/Bax/caspase-3, Akt/Nrf2/Gpx4, ROS/pkcδ/NF-κb, and Bcl-2/Bax signaling pathways (Sun et al., 2012; Dong et al., 2015; Zheng et al., 2016; Guo et al., 2021; Wang et al., 2022).