Astragaloside IV and Calycosin are bioactive compounds of Astragalus mongholicus Bunge (huang qi), they could protect dopaminergic neuron against neuroinflammation and oxidative stress, prevent dopaminergic neurodegeneration and mitigate PD symptoms, via regulating signaling ways of TLR/NF-κb and MAPK, Nrf2, nfκb/NLRP3, JAK2/STAT3, PI3K/AKT/mtor, and p38 MAPK signaling pathways (Chan et al., 2009; Liu et al., 2017; Yang C. et al., 2019; Yang J. et al., 2019; Tan et al., 2020; Xia et al., 2020; Xu et al., 2021). The gene discussed is NFKB1; the disease is Parkinson disease.