MTAs can be divided into two main categories: microtubule-stabilizing agents (MSAs) (Zhao et al., 2016) and microtubule-destabilizing agents (MDAs) (Borys et al., 2020), and they have been studied in many cancers (Karahalil et al., 2019; Khwaja et al., 2021; Anwar et al., 2022; Chen, 2023), epithelial ovarian cancer (Tymon-Rosario et al., 2021), non-small cell lung cancer (NSCLC) (Tagliamento et al., 2019), etc. Therefore, as the microtubule-encoding gene, TUBB’s mediating functions in cancers should be noticed and clarified. The gene discussed is TUBB; the disease is cancer.