CD4 and neoplasm: Moreover, we utilized seven algorithms and found that in almost every cancer the TUBB mRNA expression level was positively related to the abundance of CD4+ T helper 1 (Th1) cells, characterized by the production of proinflammatory cytokine interferon-gamma (IFN-γ), plays a central role in orchestrating cell-mediated immunity against tumor cells (Yang et al., 2020).