The results revealed a notable downregulation of AVPR1A, FEZ1, HGF, GSN, NEDD9, and EGR3 expression in the breast cancer cell lines (MCF7, BT-474, SK-BR-3, MDA-MB-231) when compared to the normal mammary epithelial cell line (MCF-10A). The gene discussed is EGR3; the disease is breast carcinoma.