APOE and Alzheimer disease: From these polymorphisms, researchers in Korea and China have studied rs2075650 polymorphism from both TOMM40 and APOE gene(s), which has shown to have a susceptibility to AD with their population (1,477 cases and 1,950 controls) with a p-value of 0.016 (Chung et al., 2013; Ma et al., 2013; Chung et al., 2014).