Defined as an AL requiring active therapeutic intervention (administration of antibiotics, interventional drainage, or transanal drainage). Such leaks are usually managed without operative reintervention. Clinical symptoms associated with Grade B leaks include mild/moderate discomfort with abdominal/pelvic pain, leukocytosis, elevated serum C-reactive protein (CRP), and turbid/purulent rectal or vaginal discharge. Radiological evaluation conducted on these patients show leakage of the endoluminally administered contrast agent at the anastomosis. CT scans may also reveal abscess formation. This evidence concerns the gene CRP and Increased total leukocyte count.