Defined as an AL requiring relaparotomy. This can include performing a Hartmann's procedure or creating a protective ileostomy. Clinical symptoms associated with Grade C leaks include severe discomfort, leukocytosis, elevated serum CRP, abdominal pain, fever, purulent/fecal drainage, and signs of sepsis/peritonitis (abdominal wall rigidity, tenderness to palpation, tachycardia, hemodynamic instability, leukopenia, hypothermia, organ failure, etc.). Radiological evaluation conducted on these patients reveals considerable leakage at the anastomotic site with fluid collection(s). The gene discussed is CRP; the disease is Sepsis.