RA = rheumatoid arthritis; CV = cardiovascular; CVD = cardiovascular; QUEST = Questionnaires in Standard Monitoring of Patients; DMARDs = disease-modifying antirheumatic drugs; TNF = tumor necrosis factor; SCORE = Systematic Coronary Risk Evaluation; EULAR = European League Against Rheumatism. The gene discussed is TNF; the disease is rheumatoid arthritis.