On the contrary, a retrospective study of 44 women with autoimmune disorders (connective tissue disease/mixed connective tissue disorder, systemic lupus erythematosus, systemic sclerosis, systemic vasculitis) demonstrated a protective effect of a GnRH-a on ovarian reserve parameters after receiving cyclophosphamide. This evidence concerns the gene GNRH1 and systemic lupus erythematosus.