That patient was aged 13 with a DOCK8 gene mutation (PID); she received chemotherapy (CED of 1828 mg/m2) only eight months post-menarche, and she had an undetectable estradiol (E2) level and FSH level of 2.4 IU/L at a time-point 36 months post-HSCT, which connotes hypothalamic hypogonadism. This evidence concerns the gene BRD2 and pelvic inflammatory disease.