-High expression of miR-149 decreases MyD88 protein expression and production of inflammation inducers such as TNF-α, IL-6, and NF-κB in response to LPS stimulation-miR-149 is able to directly target the 3′-UTR of MyD88 mRNA.-This micoRNA via regulating TLR/MyD88 signaling pathway has an important immunomodulatory role in sepsis pathogenesis. The gene discussed is IL6; the disease is Sepsis.