These include the epilepsy genes CACNA1A, CDKL5, CHRNA4, GRIN2B, NRXN1, PNKP, POLG, SCARB2, SCN1A, and SCN2A as well as the cardiac genes ANK2, KCNE1, KCNQ1, RYR2, SCN5A, and SCN10A (26, 30, 31, 33, 34, 71, 72). Here, POLG is linked to epilepsy.