Alms1 KO rats are reported to be hypertensive, attributed to altered tubular trafficking of the Na+/K+/2Cl− (NKCC) co-transporter, and hypertension is observed in ∼30% of patients with AS (Marshall et al., 2005; Edwards et al., 2015; Brofferio et al., 2017). The gene discussed is ALMS1; the disease is hypertensive disorder.