Transcriptional analysis of the heart of male and female global Alms1 KO mice at 24 weeks of age was undertaken next to evaluate markers of cardiomyopathy as before, with the addition of two genes associated with fibrosis, i.e. alpha-1 type I collagen (Col1a1) and lysyl oxidase (Lox), and three genes involved in cell cycle regulation and cellular senescence, i.e. cyclin dependent kinase inhibitor 1A (Cdkn1a), cyclin dependent kinase inhibitor 2A (Cdkn2a) and lamin B1 (Lmnb1). The gene discussed is LMNB1; the disease is cardiomyopathy.