ALMS1 and obesity due to melanocortin 4 receptor deficiency: Diastolic dysfunction has been associated with non-cardiac drivers, such as hypertension, diabetes and obesity (Noll et al., 2020), and we have reported that the line of global Alms1 KO mice used in this study is, like other global KO models described previously, obese and insulin resistant (McKay et al., 2024).