VEGFA and malignant colon neoplasm: Honarmand et al. found that CBD has an anti-angiogenesis effect subsequently, has an anticancer and antimetastatic effect on a group of mice with colon cancer by reducing the expression of VEGF (vascular endothelial growth factor) in cannabidiol-treated mice more than the non-cannabidiol-treated control group (Honarmand et al. 2019).