Another mechanism by which CBD induces apoptosis is increasing the expression of death receptor-5 (DR5), to which TNF-Related Apoptosis-Inducing Ligand (TRAIL) binds and stimulates apoptosis in colorectal cancer cells, which in return increases the sensitivity to TRAIL leading to increased apoptosis in CRC, but it didn’t affect the normal colorectal cells . The gene discussed is TNFRSF10B; the disease is colorectal cancer.