CNR1 and cancer: They found that there is a significant increase in the expression of CB1 and CB2 receptors in cancer-associated fibroblasts (CAFs) compared to the normal fibroblasts (HFPs), although treating the HFPs and CAFs with CBD showed more decrease in the viability than WIN-55, this indicates that CBD acts through different receptors, such as peroxisome proliferator-activated receptor (PPAR)-γ (Pietrovito et al. 2020).