POMC and alexithymia: The issue directly based on unconscious processing and traumatic experiences underlying alexithymia involves an early hypermetabolic state implying the activation of sympathetic nervous system through the start-up of neuroendocrine axis, based on corticotropin release factor, the increase in catecholaminergic and mineralocorticoid activity, to produce a dopaminergic and glutamatergic dysregulation [136].