CRP and acute chest syndrome: The prediction of ACS was determined with a ROC curve (Fig. 2): a total bilirubin > 39 mg/L (AUC: 0.79, sensitivity: 83.3%, specificity: 71.1%), non-HDL-C < 64.5 mg/dL (AUC: 0.746, sensitivity: 66.7%, specificity: 73.8%), CRP > 8.5 mg/L (AUC: 0.82, sensitivity: 66.7%, specificity: 83.3%) and an immature reticulocyte count of > 117.5 109/L (AUC: 0.80, sensitivity: 80%, specificity: 72.6%) were associated with ACS.