Of note, Chambers et al. have followed up London resident Indian Asians, for 8 years, and found that DNA methylation levels of TXNIP, PROC, C7orf29, SREBF1, PHOSPHO1, SOCS3 and ABCG1 were positively associated with future T2DM incidence [71], but similar studies are lacking in Indians living in India, where exposure to pollution and availability and consumption of healthy diet are vastly different. Here, TXNIP is linked to type 2 diabetes mellitus.