In a 1:1 matched nested case–control study of 290 incident diabetics, who developed T2DM and 290 controls, who remained normoglycemic during the 4-year follow-up, baseline methylation at 7 CpG sites of IGFBP2 in blood cells (4 hypermethylated and 3 hypomethylated in cases) was associated with increased risk of incident T2DM [70]. The gene discussed is IGFBP2; the disease is type 2 diabetes mellitus.