In a longitudinal study of Indian Asians living in London, UK (1074 incident T2DM and 1590 normoglycemic controls), over 8 years of follow-up, Chambers et al. reported that DNA methylation levels of TXNIP, PROC, C7orf29, SREBF1, PHOSPHO1, SOCS3 and ABCG1 in blood cells were positively associated with future T2DM incidence [71]. The gene discussed is SREBF1; the disease is type 2 diabetes mellitus.