KCNQ1 and type 2 diabetes mellitus: Though Toperoff et al. reported hypomethylation of KCNQ1 in blood cells [58], there are no human pancreatic islet studies reporting hypomethylation of KCNQ1. Identification of multiple variants in genome-wide association studies [73–81] points toward the likely importance of KCNQ1 in T2DM pathophysiology.