From the 32 studies that report differentially methylated genes/loci between T2DM and normoglycemic individuals, ABCG1 (hypermethylated in blood), FTO (hypermethylated in blood and spermatozoa), KCNQ1 (hypermethylated in blood and hypomethylated in spermatozoa), TXNIP (hypomethylated in blood), PPARGC1A loci at chr4: 24,111,501–750 (hypermethylated in skeletal muscle and spermatozoa) and loci at chr4: 24,024,251–500 (hypomethylated in spermatozoa), PTPRN2 (hypermethylated in blood, hypomethylated in adipose tissue) were reported in more than one study. The gene discussed is TXNIP; the disease is type 2 diabetes mellitus.