Walaszczyk et al. [9] could replicate association of methylation with T2DM in blood samples from the Lifelines study at 5 CpGs (in ABCG1, LOXL2, TXNIP, SLC1A5 and SREBF1) out of the 52 CpGs they identified as reported to be differentially methylated in T2DM through a systematic review of the literature done till April 2017. The gene discussed is TXNIP; the disease is type 2 diabetes mellitus.