Moreover, it sustains and induces melanoma aggressiveness, via an autocrine pathway involving IL-8 and its receptor C-X-C motif chemokine receptor 2 (CXCR2) and recruits macrophages at the tumor site by inducing a M2 phenotype in in vivo zebrafish and mouse models of melanoma [19]. Here, CXCR2 is linked to melanoma.