In MDA-MB-231 cells, all the tested genes were significantly downregulated in si-Bcl-2 condition, except for TEAD4, while only for TEAD2 transcript a significant modulation was observed in Bcl-2 silenced H460 cells (Supplementary Fig. S3), suggesting that Bcl-2 can affect Hippo pathway depending on the tumor histotype. The gene discussed is TEAD4; the disease is neoplasm.