This evidence was confirmed when A375 (Fig. 7C-F) and M14 (Supplementary Fig S6) clones stably overexpressing Bcl-2 were plated on different stiffness gels: increased cell viability respect to control was observed when Bcl-2 overexpressing melanoma cells were plated in both 1 kPa and 50 kPa (Fig. 7C, D, Supplementary Fig. 5C, D). The gene discussed is BCL2; the disease is melanoma.