As YAP is required for the invasive and migratory ability of melanoma cells [23] and Hippo pathway activation results in changes of ECM stiffness [35], a property of solid tumor relevant for cancer progression and resistance to treatment [35, 68], we also evaluated whether the Bcl-2/YAP axis was crucial in mediating some cellular processes, such as cell migration and proliferation in response to different stiff condition of culture. Here, BCL2 is linked to cancer.