CCN1 and proliferative diabetic retinopathy: Additionally, in scRNA-Seq data from an oxygen-induced retinopathy (OIR) model, which is commonly used to mimic ischemic retinopathies such as retinopathy of prematurity and proliferative diabetic retinopathy [42], we observed CCN1 highly expressed in Müller cells, pericytes, endothelial cells, neural stem cells, and astrocytes (Fig. S2C).