Our findings showed that ENTPD2 was released via exosomes from colon cancer cells to suppress CD8+ T-cell function by both limiting ATP-P2  X7 receptor (P2  X7R)-mediated NFATc1 nuclear transcription and promoting the activity of the adenosine-A2AR pathway (Fig. 7K). Here, NFATC1 is linked to malignant colon neoplasm.