Subsequently, we evaluated exosomes derived from ENTPD2-knockdown colon cancer cells (ExoRKO−shENTPD2 and ExoDLD1−shENTPD2) and control colon cancer cells (ExoRKO−shNC and ExoDLD1−shNC), with the corresponding cell lysates used as controls. The gene discussed is ENTPD2; the disease is malignant colon neoplasm.