It may be potentiated by multiple factors including volume depletion such as hypercalcemia or diuretic use, infections, nonsteroidal anti-inflammatory drug (NSAID) use, IV contrast (the prevalence of contrast-associated AKI is 0.6–1.25% in patients with MM), acidic urine, high urine sodium level, and renin-angiotensin blockers [3, 4, 16]. The gene discussed is REN; the disease is Hypercalcemia.