Acute kidney injury appeared less than in the insulin group than in the non-insulin group (10.2% vs. 7.8%, p = 0.033), and the patients using invasive mechanical ventilation and ECMO were more in the insulin group than in the non-insulin group (invasive mechanical ventilation, 10.6% vs. 3.0%, p < 0.001; ECMO, 1.2% vs. 0.3%, p = 0.001; Table S1). The gene discussed is INS; the disease is acute kidney injury.