Specifically, attention should be paid to the frequency and mutual association of TP53 mutations and 17p deletions, frequency of low-burden mutations, and TP53 mutation profile, which is similar to other cancers with a very few exceptions, such as a high prevalence of variant c.626_627del p.Arg209Lysfs in CLL [82] (Fig. 4). The gene discussed is TP53; the disease is cancer.