Furthermore, compared to controls, A2780 and SKOV3 cells cocultured with Exo or Exo-shNC exhibited increased the expression of MMP9, Vimentin and Snail but decreased the expression of E-cadherin that were highly associated with cancer invasiveness and metastasis27–30, but these effects were abolished by Exo-shcircTMCO3#1 or #2 coculture (Fig. 3f). Here, MMP9 is linked to cancer.