CD4 and neoplasm: Tumor ICD-promoted mature DCs can present antigens to naïve T cells, further promoting their differentiation into CD8 or CD4 and ultimately eliciting a T-cell immune response40,41, we next investigated whether co-culture of zebularine-pretreated tumor cells, BMDCs, and mouse splenic lymphocytes more effectively promotes T cell priming (Fig. 2p).