In summary, our findings indicate that the DNMTi zebularine induces tumor immunogenic cell death via translocation of Calr from the ER lumen to the cell membrane surface, ATP release from tumor cells into the extracellular space, activation of APCs, enhanced phagocytosis by APCs, activation of IFN signaling, and upregulation of antigen processing and presentation genes. This evidence concerns the gene IFNA1 and neoplasm.