Our single-cell RNA-seq data showed that zebularine treatment of melanoma cells significantly upregulated a panel of MHC-AgPPM genes (Fig. 5a–c and Fig. 6a), innate immune-associated genes (IFN-stimulated genes, chemokines, etc.; Supplementary Fig. 10a), and genes involved in lymphocyte adhesion (such as Vcam1, Icam1, Icam2, and Sele; Supplementary Fig. 10b–d). This evidence concerns the gene VCAM1 and melanoma.