We observed that the anti-tumor effect of zebularine was abolished in the presence of anti-CD8 or anti-CD4 antibodies (Supplementary Fig. 3h) in B16F10 tumor-bearing mice (Fig. 3c, d, Supplementary Fig. 3i and Supplementary Fig. 3k) or MC38 tumor-bearing mice (Fig. 3e and Supplementary Fig. 3j and Supplementary Fig. 3l). Here, CD4 is linked to neoplasm.