Moreover, we revealed that cGAS-STING–induced activation of NF-κB and IFNβ signaling drives the innate immune response to DNMTi and further activates MHC (major histocompatibility complex) antigen processing and presentation machinery (AgPPM) to initiate more effective CD4+ and CD8+ T cell killing of tumor cells. This evidence concerns the gene CD8A and neoplasm.