Zebularine treatment results in the translocation of Calr from the ER lumen to the cell membrane surface, release of ATP from tumor cells, and induction of IFN and chemokine production, which subsequently stimulates the maturation of DCs and enhances APC-driven phagocytosis and the cross-presentation of tumor antigens to T cells (Fig. 2). This evidence concerns the gene IFNA1 and neoplasm.