Importantly, multivariate analysis showed that hypoalbuminemia was also a strong prognostic factor when considered in conjunction with elevated LDH serum levels for both OS (albumin: HR = 4.33, 95% CI 2.22–8.45, Cox P = 1.74e−05, LDH: HR = 2.70; 95% CI 1.35–5.43, Cox P = 5.15e−03, Fig. 3e) and PFS (albumin: HR = 4.91 95% CI 2.66–9.06, Cox P = 3.55e−07; LDH: HR = 2.29, 95% CI 1.17–4.50, Cox P = 1.58e−2, Fig. 3f). Here, ALB is linked to Hypoalbuminemia.