ADAM9 and infection: Analysis of EMCV loads in the heart revealed that Adam9 KO mice had significantly higher serum (Fig. 1B) and cardiac (Fig. 1C) titers of EMCV compared to WT mice as early as 24 h p.i. The increased viral load in the hearts of EMCV-infected Adam9 KO mice led us to investigate whether the earlier mortality seen in these mice was due to infection-mediated cardiac pathology.