The exact pathways in which the impaired phospholipids (due to mutations in AGPAT2 and BSCL2) lead to impaired response to infection have yet to be determined, but here we propose candidates as: Endocytosis (e.g. clathrin-mediated endocytosis); collagen metabolism; immune synapse (e.g. antigen presentation, IFN-γ signaling, JAK/STAT); NF-kappaB signaling; and irregular PtdIns biosynthesis. This evidence concerns the gene IFNG and infection.