The following pathways involved in the highest participation of targets: AGE-RAGE signaling pathway in diabetic complications (17 targets, 32.69%), such as NOS3, TNF, PIK3CA, AKT1, et al. Pathways in cancer (17 targets, 32.69%), such as NOS2, TNF, PIK3CA, AKT1, HMOX1, NFE2L2, et al. Fluid shear stress and atherosclerosis (14 targets, 26.92%), such as NOS3, TNF, PIK3CA, AKT1, HMOX1, NFE2L2 et al. The gene discussed is TNF; the disease is atherosclerosis.