GCG and Insulin resistance: Our study showed that DFU patients with lower BMI were more likely to be malnourished, which was consistent with previous conclusions [7].This may be attributed to the negative correlation between BMI and insulin resistance [24], in other words, people with lower BMI exhibit higher levels of insulin and glucagon which will aggravate the metabolism disturbances of the endocrine system, causing a reduction in the synthesis of energy-supplying substances like protein.