CBS and hypertensive disorder: In healthy individuals, bivariate correlation analysis showed that fibrin CLT was associated with uCys, uCysGly, and ten other variables: CBS T833C 844ins68 polymotphism (β = 0.12, P = 0.035), uCreatinine (β = − 0.18, P = 0.001), total cholesterol (β = 0.17, P = 0.003), LDL-cholesterol (β = 0.14, P = 0.022), triglycerides (β = 0.11, P = 0.062), BMI (β = 0.19, P = 0.001), hypertension (β = 0.17, P = 0.003), earlier CVD (β = 0.12, P = 0.043), age (β = 0.23, P = 0.000), and Absmax (β = 0.55, P = 0.000) (Table 4).