In healthy individuals, fibrin Absmax was associated with uHTL (β = − 0.14, P = 0.018), uHcy (β = − 0.13, P = 0.043), uCys (β = − 0.14, P = 0.014), uCysGly (β = − 0.12, P = 0.038), and ten other variables: uCreatinine (β = − 0.14, P = 0.014), anti-N-Hcy-protein autoantibody (β = 0.13, P = 0.028), total cholesterol (β = 0.22, P = 0.000), LDL-cholesterol (β = 0.22, P = 0.000), triglycerides (β = 0.13, P = 0.024), BMI (β = 0.29, P = 0.000), hypertension (β = 0.13, P = 0.024), other heart disease (β = 0.14, P = 0.019), age (β = 0.33, P = 0.000), and fibrin CLT (β = 0.55, P = 0.000) (Table 4). The gene discussed is PROS1; the disease is heart disorder.