TARDBP and amyotrophic lateral sclerosis: Part of the deamidation of asparagines found in TDP-43 in the brain samples might be produced by the sample processing; however, since all the samples were processed in the same way, the fact that deamidation was found more frequently in ALS patients than in controls support deamidation of TDP-43 as a process naturally occurring in vivo and associated with the disease.