Notably, RRPC11,20,22 had greater expression of PHF19 than other clusters (RRPC11: Log2FC = 2.43, P < 0.001 and FDR < 0.001; RRPC20: Log2FC = 3.08, P < 0.001 and FDR < 0.001; RRPC22: Log2FC = 2.77, P < 0.001 and FDR < 0.001, Fig. 3A, B), an epigenetic modifier whose expression is highly predictive of poor prognosis in myeloma patients13. The gene discussed is PHF19; the disease is plasma cell myeloma.