PROM1 and neoplasm: At later time points (16 weeks), when PDAC is detectable, expansion of EpCAM+Sca-1+ cells was more pronounced (figure 2B), and EpCAM+Sca-1+ cells could be partitioned using CD133 expression, with higher levels observed in KPC vs KP pancreata (figure 2C), translating into higher spheroid forming capacity (figure 2D), higher tumour propagating capacity in an extreme limiting dilution assay (ELDA) (figure 2E) and sustained long-term (ie, serial transplantation) tumorigenicity (figure 2F).