Among the significantly upregulated genes, we identified Pglyrp1, which has a role in innate immunity as an antibacterial protein and participates as a proinflammatory factor in autoimmune diseases.53 54 Recently, it has been described as a protumour protein produced by T cells in some cancers.32 Furthermore, has been identified in the PDAC secretome.37 55 However, its functional role in PDAC had never been studied before. The gene discussed is PGLYRP1; the disease is autoimmune disease.