Among the significantly upregulated genes, we identified Pglyrp1, which has a role in innate immunity as an antibacterial protein and participates as a proinflammatory factor in autoimmune diseases.53 54 Recently, it has been described as a protumour protein produced by T cells in some cancers.32 Furthermore, has been identified in the PDAC secretome.37 55 However, its functional role in PDAC had never been studied before. This evidence concerns the gene PGLYRP1 and cancer.