In agreement, another study using oesophageal cancer cells showed that PGLYRP1 modulates TNFα-tumour necrosis factor receptor 1 (TNFR1) signalling by binding TNFR1.37 Thus, we hypothesised that TNFα might regulate PGLYRP1 in PDAC CSCs. This evidence concerns the gene PGLYRP1 and carcinoma of esophagus.