CXCR2 and neoplasm: Although there is a reduction in neutrophil numbers in OE tumours, a transcriptional analysis of these tumour-associated neutrophils (TANs) revealed that OE-infiltrated TANs express lower levels of migration-related genes (eg, Cxcr2 and Cxcr4) and, interestingly, higher levels of immunosuppressive molecules, including Pglyrp1 (online supplemental figure S5A), compared with WT tumours.