We found several high-scoring genes for which extensive evidence on their role in obesity already exists, such as MC4R,48,49,50,51BDNF,52,53,54GIPR,55,56,57DGKI,21MTOR,58,59AKT3,60 and LEPR61,62 (Table S9). This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.