We next built a prioritization score that weighs each of the eight methods based on whether or not they prioritized one or more of the six established obesity genes located in any of the 536 BMI-associated loci (i.e., LEPR, POMC, PCSK1, DGKI, SH2B1, and MC4R). Here, SH2B1 is linked to obesity due to melanocortin 4 receptor deficiency.