SH2B1 and obesity due to melanocortin 4 receptor deficiency: Several of the high-scoring genes (score ≥ 11) are known to be implicated in obesity (such as DGKI [score: 22.8], MC4R [19.6], BDNF [19.6], MTOR [16.8], SH2B1 [14.8], GIPR [14.3], AKT3 [11.6], and LEPR [11.6]).