Our gene prioritization pipeline also identified genes encoding known therapeutic targets for obesity and its comorbidities, such as the glucose-dependent insulinotropic polypeptide (GIP) receptor, GIPR (14.3), and the fibroblast growth factor 21 (FGF21) co-receptor, FGFR1 (17), and a gene encoding a subunit in the NMDA receptor, GRIN3A (14.3). This evidence concerns the gene FGF21 and obesity due to melanocortin 4 receptor deficiency.