Additionally, severe COVID-19 cases exhibit increased circulation of EG proteoglycans (syndecan-1, HS, and hyaluronan) and markers of endothelial injury (vascular endothelial growth factors, angiopoietin-1, and soluble thrombomodulin), compared to non-severe and uninfected cases [1,2,4,5]. The gene discussed is SDC1; the disease is COVID-19.