linc-ADAIN (previously named linc-DMRT2) was identified as an inflammatory modulated lincRNA by our laboratory through deep RNA sequencing (RNA-seq) of gluteal subcutaneous white adipose tissue (sWAT) from healthy, non-obese volunteers in the Genetics and Evoked Responses to Niacin and Endotoxemia (GENE) study.17 Adipose expression of lincRNAs, including linc-ADAIN, was validated in lean healthy subjects from GENE (N = 25) and obese subjects from the Penn Human Adipose Resource (HAR) (N = 39). Here, DMRT2 is linked to serum lipopolysaccharide activity.