INS and obesity due to melanocortin 4 receptor deficiency: In hypertrophy, the enlargement of existing adipocytes, adipose becomes hypoxic due to limited angiogenesis, as well as inflamed and insulin resistant.40–42 This dysfunction contributes to CMDs.43 Here we uncover how linc-ADAIN, an adipose lincRNA downregulated in human sWAT during obesity, regulates adipocyte lipid storage and secretion of cytokines.