PPARG and obesity due to melanocortin 4 receptor deficiency: While the increase in PPARγ coincident with increased adipose inflammation with linc-ADAIN KD may seems counterintuitive, this combination has often been observed in adipose remodeling in both experimental models and clinical obesity.47,48 Thus, linc-ADAIN is an adipose anti-inflammatory lincRNA that can modulate lipid storage and inflammation, two key features of adipose tissue remodeling in obesity.