CXCL8 and obesity due to melanocortin 4 receptor deficiency: IL-8 is a chemokine for neutrophils, and in early stages of obesity, neutrophils infiltrate adipose tissue, producing chemokines that promote macrophage infiltration.68 Indeed, with linc-ADAIN depletion we observed increased macrophage infiltration in 16-week-old adipose explants, which may be mediated by increased IL-8.