PPARG and obesity due to melanocortin 4 receptor deficiency: KLF5 is induced early (within 1 h) during adipocyte differentiation and gradually declines thereafter.20 KLF5+/− mice have delayed adipose tissue development, have reduced lipid droplets, and are resistant to high-fat-diet-induced obesity.20linc-ADAIN depletion during adipocyte differentiation elevated KLF5 in pre-adipocytes and resulted in sustained KLF5 levels and increased PPARγ1 and 2 expression, as well as levels of adipogenic genes.