ELAVL1 and type 2 diabetes mellitus: 58 In genome-wide association studies (GWASs), the IGF2BP2 locus has been repeatedly associated with T2D.59,60 Similar to HuR, IGF2BP2 functions are tissue specific due to IGF2BP2 binding different RNAs across tissues.51 Global deletion of IGF2BP2 in mice leads to resistance to high-fat-diet-induced obesity, fatty liver, and glucose tolerance, due to increased protein but not mRNA of UCP1, which promotes increased energy expenditure.