KLF5 and cancer: KLF5 expression can promote some cancers and tumor angiogenesis.69 For example, KLF5 promoted angiogenesis in bladder cancer by directly increasing vascular endothelial growth factor A (VEGFA) transcription.70 KD of lncRNA MCM3AP-AS1 increases miR-211, which targets KLF5 and inhibits its expression, affecting angiogenesis in glioblastoma.71 Interestingly, IL-8 is also known as a pro-angiogenic factor, particularly in cancer.72 In our pathway analyses of adipocyte RNA-seq data from linc-ADAIN KD vs. scramble control, angiogenesis was one of the top biological processes identified.