However, the appearance of a neutrophil subpopulation expressing features of senescence (upregulation of p21, growth arrest, upregulation of BCL2 and/or BCL-XL) was unexpected, although perhaps not unprecedented, as a similar neutrophil population expressing features of senescence has recently been described in the setting of prostate cancer (39). The gene discussed is CDKN1A; the disease is Familial prostate cancer.