Peutz-Jeghers syndrome (carriers of germline pathogenic mutation in STK11/LKB1), FAMMM (carriers of pathogenic germline CDKN2A mutation), Hereditary Pancreatitis (carriers of a pathogenic mutation in PRSS1), and carriers of a germline pathogenic mutation in BRCA1, BRCA2, with at least one first degree relative with pancreatic cancer. This evidence concerns the gene CDKN2A and hereditary chronic pancreatitis.