By screening the 14 clusters of cells in the transcriptomic RNA-seq dataset, 8 clusters had significant differences in the abundance of their signature genes in kidney between AKI and control mice, including Egr1 + PT-C1, Tfrc + PTC-C2, Jun + PTC-C3, Cxcl2 + Mac-C1, Ctsb + Mac-C2, l1b + Mac-C4, Egr1 + Fib-C1, and Gpx4 + Fib-C4. The gene discussed is C2; the disease is acute kidney injury.