A total of 8 clusters of cells, including Egr1 + PTC-C1, Tfrc + PTC-C2, Jun + PTC-C3, Cxcl2 + Mac-C1, Ctsb + Mac-C2, l1b + Mac-C4, Egr1 + Fib-C1, and Gpx4 + Fib-C4, had significant differences in the abundance of their signature genes infiltrating the kidneys between AKI and control mice. Here, CTSB is linked to acute kidney injury.