With high affinity and selectivity for α-syn over Aβ and tau proteins (α-syn fibrils KD: 10.97 nM, Aβ fibrils KD: 109.2 nM, tau fibrils KD: 120.5 nM), a significant advancement, [18F]F0502B enables more precise detection of α-synuclein aggregates, a crucial pathological hallmark of synucleinopathies. Here, MAPT is linked to synucleinopathy.