Proteomic studies have revealed that electronegative LDLs isolated from patients with familial hypercholesterolemia (FH) or diabetes mellitus (DM) contain lipoprotein-related phospholipase A2 (Lp-PLA2) [15, 16], which induces endothelial inflammation and pathologic changes that lead to ASCVD [17]. Here, PLA2G7 is linked to diabetes mellitus.