Here we report a patient with initial diagnosis of Rubinstein-Taybi syndrome (RSTS, OMIM #180849, #613684), another chromatinopathy which causative genes CREBBP or EP300 encode for two HATs (Petrif et al. 1995; Roelfsema et al. 2005). Here, CREBBP is linked to Rubinstein-Taybi syndrome.