CD8A and neoplasm: Interferon gamma (IFN-γ) released by CD8+ T cells downregulates the expression of two subunits, SLC3A2 and SLC7A11, of the glutamate-cysteine antiporter system, impairing tumor cell uptake of cysteine, thereby promoting lipid peroxidation and ferroptosis in tumor cells (Lang et al. 2019).