HMGA2 and breast cancer: In MCF7/R and MDA-MB-231 cells, HMGA2 overexpression enhances cell invasion ability, inhibits apoptosis, and restores the influence of sh-circTRIM28, suggesting that sh-circTRIM28 inhibition can restore BC progression by targeting miR-409-3p/HMGA2 signaling (Yang et al. 2022).