There is increasing evidence suggesting that transcriptional regulation mediated by HMGA2 is a key factor in BC metastasis (Sun et al. 2013), and deeper understanding of the molecular mechanisms underlying BC has led to the recognition of specific targets (Velikyan 2020), which can be used to diagnose and treat individuals, thereby improving treatment efficacy (Jokar et al. 2021). This evidence concerns the gene HMGA2 and breast cancer.