HMGA2 and breast cancer: Furthermore, circARL8B overexpression eliminates the inhibitory effects of miR-653-5p on BC (MCF-7 and MDA-MB-231) cell development, while circARL8B knockdown restrained BC cell viability, invasion, and fatty acid metabolism by regulating miR-653-5p/HMGA2 signaling (Wu et al. 2021).