The efficacy of carcinoembryonic antigen (CEA)-specific CAR-T cells combined with recombinant human IL‐12 (rhIL‐12) [87] has been explored in several types of solid tumor models with high CEA expression, such as the colorectal cancer cell line HT-29, pancreatic cancer cell line AsPC-1, and gastric cancer cell line MGC803. Here, CEACAM5 is linked to familial pancreatic carcinoma.