Finally, the higher anti-cancer capability of the Klf1(K74R) mice did not appear to depend on the arginine at codon 74 since Klf1(K74A) mice carrying K→A amino acid substitution at the K74 sumoylation site also exhibited higher anti-metastasis capability than WT mice in the pulmonary foci assay (Figure 1D). This evidence concerns the gene KLF1 and cancer.