On the other hand, the DEPs in elder Klf1(K74R) leukocytes were also enriched for anti-cancer pathways related to the IFN-α response, TGF-β signaling, etc. (Ni and Lu, 2018; Principe et al., 2014; Zitvogel et al., 2015; Figure 5E), while DEPs in the elder WT leukocytes were enriched for the pro-cancer pathways related to IL-6-JAK-STAT3 signaling and angiogenesis (Zhao et al., 2016). This evidence concerns the gene IL6 and cancer.