STAT3 and cancer: To understand the correlations of these proteins with aging and cancer, we performed the Gene Set Enrichment Analysis (GSEA) and found that the age-dependent DEPs changed in the concordant direction in the WT and Klf1(K74R) mice were enriched for several known aging-related pathways, for example, IL-6-JAK-STAT3 signaling, DNA repair, etc. (Fabian et al., 2021; Figure 5B).