This data, together with the higher level of NK cells in aged Klf1(K74R) mice (Figure 4—figure supplement 1), indicated that in parallel to the leukocytes (Shyu et al., 2022), NK cells also play an important role in the higher anti-cancer capability of the hematopoietic blood system of Klf1(K74R) mice, as exemplified in Figures 2 and 3. The gene discussed is KLF1; the disease is cancer.